It's exactly the same feeling. It would take a long time to explain why but the short version of it all is that it doesn't matter. Even on extremely supple MTB tires where a pressure variation of 1-2 psi matters immensely I can barely tell the difference if the tire is inflated with CO2 or with regular air. Long term I can, but only because they deflate at different rates. While riding there's no difference. There are some non-CT125 reasons to think twice when using CO2, but that isn't specific to CO2[1]. CO2 is perfectly fine.
[1] If you're running a slime tubeless setup, CO2's rapid temperature change can cause the sealant to coagulate. However that is a gas pressure law and slime sealant thing, and would happen no matter what gas you were using. Additionally, as you hold the CO2 inflator, it will change temperature for the same reason, so you should wear gloves to avoid frost burns. Again, a gas pressure law thing, not a CO2 thing.